Fungicide Delivery

Efficient Fungicide Delivery

Most antifungal therapies struggle to enter fungal cells efficiently and lack the specificity needed to minimize collateral damage to host cells. The result is poor potency, high systemic exposure, widespread toxicity, and growing resistance. Dose escalation remains the default strategy—especially in the lungs, and specifically in invasive fungal infections like pulmonary aspergillosis, where dense mucus and fragile tissue make precision delivery even harder. Phoreus created water soluble PNP which allows therapeutic payload to reach sites of pathogen infection without overwhelming the rest of the body. Initial applications focus on difficult to treat pulmonary infections like Aspergillus and Candida auris.

Advantages of PNPs in Fungicide Delivery

Phoreus’ PNPs are addressing the major challenges of fungicide delivery, aiming for a safer, more efficient, and patient-friendly solution. Here’s how:

• Improved Bioavailability: PNPs are designed to enhance the amount of fungicide that reaches its target, potentially supporting better therapeutic outcomes with reduced active ingredient requirements.
• Reduced Cost of Goods: By enhancing bioavailability, PNPs could lower the amount of drug needed, significantly cutting production costs.
• Fewer Side Effects: Unlike traditional systems that rely on permeability enhancers (which can cause gastrointestinal issues), PNPs are designed to support absorption without these additives, potentially enhancing patient comfort.

Phoreus PNPs are not just improving fungicide delivery, they’re paving the way for more accessible, patient-centric therapies that could transform care for this difficult-to-treat class of diseases.