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February 2024

The Importance of Low-Toxicity Nanoparticles

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Nanoparticles have revolutionized medical drug delivery, offering unparalleled precision and efficiency in treating various health conditions. However, inflammation and other toxicological effects remain a primary concern for human health applications. 

At Phoreus Biotech, we strive to keep you and your research at the forefront of this innovation by specializing in developing advanced nanocarrier technologies. These microscopic carriers, engineered to deliver drugs directly to targeted cells, minimize side effects and maximize therapeutic benefits. Their unique nanomaterial properties allow for the controlled release and absorption of medications without compromising safety, making them indispensable in modern medicine. 

Let’s explore the risks of nanotoxicity and how Phoreus’ platform nanotechnologies overcome these issues. 

Types of Toxicity

The toxicity of nanoparticles is a critical concern when scientists apply nanomaterials to biological systems. Due to their size and surface properties, these tiny particles can potentially cause various adverse effects such as inflammation, cell death (apoptosis), oxidative stress, and genotoxicity.

  • Inflammation: When nanoparticles interact with immune cells, they can trigger an inflammatory response. The body recognizes these particles as foreign entities, which leads to potential chronic inflammation. This inflammation disrupts normal tissue function and contributes to various diseases.
  • Cell Death (Apoptosis): Nanoparticles can induce cell apoptosis by interfering with normal cellular processes. This programmed cell death, while a natural occurrence, can be problematic if it leads to the premature death of healthy cells, affecting tissue health and functionality.
  • Oxidative Stress: These particles can generate reactive oxygen species (ROS), leading to oxidative stress. This imbalance between the production of free radicals and the body’s ability to detoxify their harmful effects can result in significant cellular damage, including proteins, lipids, and DNA.
  • Genotoxicity: Nanoparticles have the potential to cause DNA damage, either directly or indirectly. This genotoxicity can lead to mutations, chromosomal fragmentation, or even carcinogenesis, posing serious long-term health risks.

Phoreus Biotech’s approach in developing nanocarriers is to minimize these risks, focusing on creating safe and effective applications for medical drug delivery.

How Innovation Reduces Nanotoxicity

Innovations in nanotechnology have significantly reduced the toxicity traditionally associated with nanoparticles, enhancing their safety in biomedical applications. By harnessing advanced nanoscience techniques and understanding particle size dynamics, researchers have developed nanomaterials that are more biocompatible and less likely to cause adverse reactions in the body. Here are some key ways innovation is reducing nanotoxicity in human health:

  • Size Optimization: By manipulating particle size, scientists can influence how nanoparticles interact with cells, reducing the potential for harmful reactions. Smaller particles, for instance, can be designed to avoid accumulation in vital organs like the spleen, thereby reducing toxicity.
  • Enhanced Imaging Techniques: Advanced imaging allows for precise monitoring of nanoparticles within the body. This precise monitoring helps in understanding their distribution, degradation, and excretion, which is crucial in toxicology studies.
  • Targeted Delivery and Inhalation Techniques: Innovations in targeted delivery systems, including inhalation methods, enable nanoparticles to reach specific sites within the body more effectively. These innovations in delivery systems reduce the overall exposure of the body to nanoparticles, minimizing potential toxic effects.
  • Regenerative Medicine: Nanomaterials are crucial in regenerative medicine, especially tissue engineering and wound healing. Their ability to mimic the extracellular matrix and support cell growth and differentiation while reducing apoptosis makes them valuable in developing new tissues or organs.
  • Reducing Drug Resistance: Nanoparticles are being explored to overcome drug resistance in various diseases, notably in cancer therapy. By facilitating the delivery of drugs to otherwise resistant cells, nanomedicine offers a promising avenue for enhancing treatment efficacy.

As nanotechnology continues to evolve, the synthesis and use of new nanomaterials and nanoparticles in medicine have extended beyond drug delivery. They are now being explored for diagnostic purposes, gene therapy, and even as direct therapeutic agents. In these applications, their reduced toxicologic effects are a crucial advantage. 

Minimizing Toxicity: Phoreus’ Approach

All new nanocarrier technology must continue to address adverse effects, ensuring that drugs are delivered safely and effectively without compromising healthy cells. Phoreus Biotech adopts a strategic nanomaterial approach to minimize the toxicity of nanoparticles:

  1. Selective Targeting: Phoreus’ nanotechnologies are designed to target specific cells or tissues. As a result, this targeting approach reduces the exposure of healthy cells to nanoparticles and lowers the risk of unintended toxic effects.
  2. Biocompatibility and Biodegradability: The nanomaterials used in Phoreus’ nanoparticles are chosen for their compatibility with the human body. They degrade safely, ensuring no long-term accumulation in the body that could lead to toxicity.
  3. Surface Modification: The surface properties of nanoparticles are meticulously engineered to minimize adverse interactions with cells. This careful engineering reduces the potential for inflammation, oxidative stress, and genotoxicity.
  4. Rigorous Testing and Validation: Phoreus Biotech emphasizes rigorous testing of its products to ensure safety and efficacy. This emphasis includes toxicology studies assessing the potential for cytotoxicity, genotoxicity, and other toxic effects in various biological models.

Through these measures, Phoreus Biotech ensures that its nanocarriers not only enhance drug delivery but do so with minimal toxicity, aligning with the highest standards of medical nanomaterial safety.

Phoreus’ Nanocarriers & Products

In an era where precision and effectiveness are paramount, nanoparticles provide a promising solution to numerous medical challenges, from cancer treatment to vaccine delivery. Phoreus Biotech’s nanocarrier technologies—BAPC, CAPC, and APC—represent significant advances in drug delivery. Here’s a quick review of these key platforms:

  • Branched Amphipathic Peptide Capsules (BAPC®️): These are robust and versatile nanocarriers capable of delivering a wide range of therapeutics. Their unique branched structure enhances stability and loading capacity, making them ideal for complex targeted delivery scenarios.
  • Corralling Amphipathic Peptide Colloids (CAPC™️): CAPC technology involves the formation of colloids that effectively encapsulate and protect therapeutic agents. This method improves the solubility and bioavailability of drugs, ensuring more efficient delivery to target cells.
  • Amphipathic Peptide Capsules (APC): APCs are designed for targeted and controlled release. Their amphipathic nature allows for effective penetration and interaction with cell membranes. This facilitates the direct delivery of therapeutics to desired sites within the body.

Applications in Drug Delivery and Uptake 

Phoreus Biotech’s nanocarriers have broad research applications, enhancing treatment development across various synthetic biology and biomedical fields. The targeted delivery system ensures that therapeutics are released precisely where needed, maximizing efficacy while minimizing side effects. This precision is particularly beneficial in treatments requiring high precision, such as chemotherapy, where targeted delivery can significantly reduce toxic uptake effects on healthy cells. 

Additionally, the enhanced stability of these nanocarriers ensures that drugs maintain their potency during transportation to the target site. This improvement in stability leads to better overall treatment outcomes. The peptide-based nanocarriers offer distinct advantages over other nanomaterial drug delivery systems like hydrogels and bioabsorbable materials. Unlike hydrogels, which may have limitations in targeting specificity, peptide-based nanoparticles ensure precise delivery to targeted cells. This precision greatly enhances treatment efficacy. 

Compared to synthetic biology techniques like viral vectors, BAPC®️, CAPC™️, and APC particles are much more versatile. Their modular design allows for the encapsulation of a broader range of therapeutic agents, from small siRNA molecules to large plasmids and macromolecules. They even accommodate CRISPR-Cas9 gene editing techniques. 

This targeted, peptide-based approach represents a significant advancement in nanocarrier technology, promising more effective, safe, and tailored treatment and delivery options.

Discover the Future of Nanoparticles With Phoreus Biotech

Phoreus Biotech continues to pioneer the use of low-toxicity nanoparticles in biomedical applications. Innovations in nanotechnology, like targeted delivery and peptide-based nanocarriers, address critical concerns, including inflammation, cell death, oxidative stress, and genotoxicity. These advancements enhance the efficacy and safety of treatments across various biomedical fields, from chemotherapy to gene editing. 

Phoreus Biotech is committed to developing safer, more effective nanocarriers to advance precision nanomedicine. Explore our innovative products and learn how they can revolutionize your research while reducing toxicity. Contact our team of experts to take the next step toward advancing your precision nanomedicine development.