Peptiplexes – A Review of Therapeutic Applications. In “Nucleic Acid Nanotheranostics: Biomedical Applications
This chapter will discuss cationic polymers containing ɛ-amine groups and immine or amide linkages that are being used as nanocarriers for nonviral gene delivery. We will focus particularly on cationic peptides. Cationic peptides, free or complexed…
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Two Separate Toxicity Studies Conducted on Apis Melifera (Honey Bees)
Introduction This report outlines two separate toxicity studies conducted on Apis melifera. The first study follows the parameters of the EPA Litmus test and the second study delves deeper into possible BAPC toxicity surpassing the…
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Assessing Branched Amphiphilic Peptide Capsules (BAPC) Delivery of Short Interfering RNA (siRNA) to Mammalian Cells
Objectives Primary: To evaluate knockdown of target protein following antisense siRNA delivery to GFP-CHO cells with BAPC versus current commercial transfection reagents. Secondary: To assess cellular viability through cryopreservation following BAPC treatment. Experimental design Transfection…
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Branched Amphiphilic Cationic Oligopeptides Form Peptiplexes with DNA: A Study of Their Biophysical Properties and Transfection Efficiency
Over the past decade, peptides have emerged as a new family of potential carriers in gene therapy. Peptides are easy to synthesize and quite stable. Additionally, sequences shared by the host proteome are not expected…
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