Physical Characteristics of 50 and 200 nm Magnetic Beads when Encapsulated with Branched Amphiphilic Peptides (BAP)
Branched Amphipathic Peptide Capsule Magnetic Beads (BAPC-MB) are a new nanoparticle developed for use as in diagnostic platforms. The bases are Maleimide Super Mag Magnetic Beads which are dispersed in 75% ethanol and combined with…
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Synthesis and Characterization of Multifunctional Branched Amphiphilic Peptide Bilayer Conjugated Gold Nanoparticles
We provide strong chemical and biophysical evidence that documents that branched amphiphilic peptides, BAPs, known to assemble into spherical nanoassemblies in solution, do assemble as peptide-bilayer-delimited capsules. These nanoassemblies are termed branched amphiphilic peptide capsules…
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Organization and Structure of Branched Amphipathic Oligopeptide Bilayers
A class of self-assembling branched amphiphilic peptide capsules (BAPCs) was recently developed that could serve as a new drug delivery vehicle. BAPCs can encapsulate solutes up to ∼12 kDa during assembly, are unusually stable, and…
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A Review of Solute Encapsulating Nanoparticles used as Delivery Systems with Emphasis on Branched Amphipathic Peptide Capsules
Various strategies are being developed to improve delivery and increase the biological half-lives of pharmacological agents. To address these issues, drug delivery technologies rely on different nano-sized molecules including: lipid vesicles, viral capsids and nano-particles….
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Thermally Induced Conformational Transitions in Nascent Branched Amphiphilic Peptide Capsules
Branched amphiphilic peptide capsules (BAPCs) are biocompatible, bilayer delimited polycationic nanospheres that spontaneously form at room temperature through the coassembly of two amphiphilic branched peptides: bis(FLIVI)-K-K4 and bis(FLIVIGSII)-K-K4. BAPCs are readily taken up by cells…
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