Gene Delivery and Immunomodulatory Effects of Plasmid DNA Associated with Branched Amphiphilic Peptide Capsules
We recently reported on a new class of branched amphiphilic peptides that associate with double stranded DNA and promote in vitro transfection of eukaryotic cells. In the present study, we tested a different formulation in…
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Synthetic In Vitro Delivery Systems for Plasmid DNA in Eukaryotes
Success for gene therapy clinical protocols depends on the design of safe and efficient gene carriers. Nature had already designed efficient DNA or RNA delivery devices, namely virus particles. However, they have a propensity to…
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Branched Amphiphilic Peptide Capsules: Cellular Uptake and Retention of Encapsulated Solutes
Branched amphiphilic peptide capsules (BAPCs) are peptide nano-spheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble to form bilayer delimited capsules. In two recent publications we described the lipid…
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