Peptiplexes – A Review of Therapeutic Applications. In “Nucleic Acid Nanotheranostics: Biomedical Applications
This chapter will discuss cationic polymers containing ɛ-amine groups and immine or amide linkages that are being used as nanocarriers for nonviral gene delivery. We will focus particularly on cationic peptides. Cationic peptides, free or complexed…
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Development of Novel Chimeric Vaccine and Delivery System for Classical Swine Fever Virus
To eliminate the need for a cold chain, DNA vaccine approach was used, in which nanoparticles composed of branched amphiphilic peptide capsules (BAPC) were employed as the DNA delivery agent. The candidate vaccine and the…
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Branched Amphiphilic Cationic Oligopeptides Form Peptiplexes with DNA: A Study of Their Biophysical Properties and Transfection Efficiency
Over the past decade, peptides have emerged as a new family of potential carriers in gene therapy. Peptides are easy to synthesize and quite stable. Additionally, sequences shared by the host proteome are not expected…
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Synthetic In Vitro Delivery Systems for Plasmid DNA in Eukaryotes
Success for gene therapy clinical protocols depends on the design of safe and efficient gene carriers. Nature had already designed efficient DNA or RNA delivery devices, namely virus particles. However, they have a propensity to…
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