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TITLE:Transdermal Delivery of Branched Amphipathic Peptide Capsule Magnetic (BAPC-MB) in Mice

To test the transdermal delivery capabilities of BAPC-MB, the tails of live mice were dipped in BAPC-MB solution for 1, 5, 15 and 30 minutes. After a 24-hour incubation period, the tissues were harvested for evaluation of tissue distribution.

This initial proof-of-concept experiment demonstrates that 50 nm BAPC-MB are rapidly absorbed transdermally and distributed to several different tissues. Although limited in scope, this work found accumulation of the beads in the lungs and spleen, with apparent excretion in the feces. Additional studies are underway to evaluate distribution to additional tissues, as well as inclusion of both oral and intravenous routes of administration.

24-Hour Incubation Period

Figure 1